New GABA amides activating GABA_A-receptors

• Peter Raster,
• Andreas Späth,
• Svetlana Bultakova,
• Pau Gorostiza,
• Burkhard König and
• Piotr Bregestovski

Beilstein J. Org. Chem. 2013, 9, 406–410, doi:10.3762/bjoc.9.42

• ; GABA; GABA-amides; GABA-superagonist; patch-clamp recording; Introduction γ-Aminobutyric acid (GABA) is the major inhibitory amino acid transmitter of the central nervous system (CNS) of vertebrates (Figure 1). It plays an important role in a variety of physiological functions, including motion